Entirely depends on your setup, and it’s probably one of those things that you won’t know until you try it unless you have the same setup as someone who has already done it successfully. I run M-Force 4 pedal bodies on the Assioma spindles (non-Shimano) and didn’t have to modify my shoes at all (Sidi Dominators, size 39).
Not sure if you’ve looked at the thread specific to the hack yet (you probably have, but I linked it just in case), but I’m pretty sure there are a few others who haven’t had to modify their shoes, and also a couple I think that have tried the new Shimano spindles with different pedal bodies.