I have a Tannus on the rear of my Felt E-bike. E-bikes are heavy, and the rear wheel takes most of the weight, which made it very susceptible to pinch flats. The Tannus fixed all that, and in the context of an E-bike I felt no difference in handling. The front remained a Gatorskin.
Looking at the tire, my guess is that on the front you would trade reliability for poorer steering feel. But, unless you are doing something that really needs feel, the puncture-proofing is a huge benefit, and I’d happily put Tannus on any kind of workhorse bike.