12 Speed 105 DI2 run GRX chainset

Evening all,
So I’ve looked at the tech sheet for both and the Q Factor is a difference of 3. And I really have no idea if it will work with no issues. 12 speed DI2 run a 12 speed GRX chainset?
And help would be fantastic

I have a 12 speed 2x GRX crankset (48-31) on my gravel bike fitted with Di2 Ultegra FD, RD, and cassette (also have an Ultegra 50-34 crankset). No issues. I just had to adjust my FD a little to make the switch from Ultegra to GRX. They use the same BB.

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