TrainerRoad + Tirzepatide (n=1)

I don’t think I’ve seen much discussion here on anyone that has actually used Tirzepatide (or Semaglutide) whilst also training with TrainerRoad, so thought I’d share my experience. Apologies, it’s turned out to be a long read.

Tl;dr: 282w FTP, 110.9kg rider starts Tirzepatide; rapidly loses weight AND fitness; recovers fitness to ~280w 3 months later, with 14kg weight drop. Struggling to raise FTP any further, with weight still dropping but at slower rate.

Brief context: I’ve always been a heavy lad. Classic rugby player build with plenty of muscle, plenty more fat - especially around the middle. Tried every type of diet and had intermittent success. Went keto in 2018 and went down from 105kg to 85-90kg, but soon ballooned back up and sat unhappily around 110kg for years.

I’ve never been a particularly great cyclist but I was pretty consistently training around 2018/19 and hit an FTP of 291 (which is only about 3w/kg for me) and did some triathlons with limited success. 2020-2022 were incredibly inconsistent with bursts of enthusiasm followed by literal months off the bike. But I was more consistent in 2023 and pretty good in 2024 (I should be clear - my consistent is 2-4 times a week, nothing crazy!) so my FTP rose from 239 in January 2024 to 282 in July. But the same day, I weighed in at 110.9kg for a distinctively average 2.45w/kg FTP.

Starting Tirzepatide (Mounjaro here in the UK): Coincidentally, the next day I started jabbing myself. Here in the UK you can get a private prescription of Mounjaro for about £175-200 a month and other than the embarrassment of having to send topless photos to the GP, it was a pretty painless process.

Unless you’ve been fat before, it’s hard for me to explain the mental shift. Literally that day, all of the food noise that I’ve had 24/7 in my head just vanished. I didn’t feel the need to snack at all that day. The next day I couldn’t finish a sandwich for lunch. That was the first time in living memory that I have not finished what was on my plate. Suddenly, I didn’t feel the overwhelming compulsion to binge. I could just… eat normally. It was literally game changing. Turns out eating well is easy when your brain is constantly telling you to eat another biscuit (or maybe the whole pack) or a bag of crisps, or a chocolate bar. Again, if you’ve never been fat this is probably difficult to understand.

Training impact: But I wanted to talk more about the impact on my training. And again, the impact was pretty immediate - but not for the better.

It genuinely felt like someone had yanked 30w out of my body overnight. I struggled to complete a 45min sweetspot. I had to reduce the intensity of an endurance ride. I completely lost my confidence in successfully riding a TR workout without drastically reducing the intensity each time. So right or wrong, I opted out of structured training. I went to the woods and rode my bike around for a bit, just enjoying myself. I don’t have a power meter so no idea how well I was riding. It took me 6 weeks to do another TR workout and although they were hard, I could complete them. End August I measured in at 271w FTP and a month later I was back up to 278w. But that 278w was now at 97kg, so my w/kg was vastly improved.

To be honest, my FTP hasn’t changed much since then. I’m sitting at 282w today. My weight loss has slowed (my wife had a baby in November so frankly I was appreciative that I’d stayed at the same weight as normally it would have skyrocketed with the stress). But I’m now sitting at 92kg and once again trending downwards. What was an FTP of 2.45w/kg is now 3.06w/kg.

Where now? Well I’d like to see what I feel like around 80kg but I’m not rushing anything. Similarly I’d like to see a 300w FTP for nothing but pure ego, but I’m not in a hurry. Consistency at low volume is what I’m aiming for. I might do some races this Summer. I’ve never done any organised ride, let alone a race, on a MTB before, nor gravel. So that sounds like fun. And if I can get somewhere near 80kg, I might even be relatively fast!

Anyway, hope that’s interesting to someone out there. Be interested to hear others’ experiences if they’ve dabbled in the Magic Jabs.

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How tall are you?

Thanks for sharing your story. That’s incredible progress. I can’t believe you were able to lose that much weight that quickly but still pretty much maintain your same FTP! Your before and after hill climb numbers must be unbelievable.

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Not very! Around 5ft7. 171cm.

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What dose are you taking? Congrats on the weight loss, I’m sure it’s affected your life in more ways than just being lighter on the bike!

I just started Semaglutide. Im 57 years old, 5-10, currently 177 lbs. I usually am around 170, but at that weight still have a bmi in low 20’s. I usually gain 10 lbs during the holidays but can drop it quickly…not anymore. Was able to drop 3lbs but that was it. I also have hypertension…if I can stay around 170, I can due without medication, but get around 180 and I require meds. Ive only been on the semaglutide a week but I have noticed no impact on my training or energy levels. I have noticed my desire to eat has diminished quite a bit, I only plan on doing it for a few months, if it works. I’d like to see 165 lbs. When I was training for tri’s and racing bike hardcore in my late 40’s I was able to stay around 158-160.

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Your experiences with GLP1ras are in keeping with what I’ve heard from many people.

They inhibit hepatic gluconeogenesis… which is an important source of muscle fuel during higher intensity exercise. Which is my guess why people notice a drop in ability to do high intensity efforts right away (that immediate drop in FTP you noticed).

Muscle loss is a know side effect of them as well - depending on the study, up to 50% of the weight loss seen is due to loss of muscle (not just fat). We are actually starting to see the rare person develop marked sarcopenia as a side effect of them.

I remember there was an old thread here where people were asking whether these would be abused by professional cyclists. Your experience is a great example of why that is unlikely to be an issue.

They are helpful when losing weight is the single most important thing on your plate to improve fitness and health. Otherwise, not so much.

Congratulations on your successful weight loss journey!

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This was one of my biggest fears when I was starting. I think by continuing to eat a ton of protein, still riding and increasing my weight lifting, I haven’t lost as much as some seem to. Though can’t deny that I’ve lost some.

I saw his case as the opposite. Lost a ton of weight and 6 months later almost back to same FTP with a far higher w/kg. Seems perfect for pros to abuse. Imagine if Jan Ulrich could have had these, for example.

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I’ve read others say the same thing. Amazing. Congratulations on your progress.

My wife tried Semaglutide and didn’t like the side effects. I tried because she had the prescription paid for. I lost 8 pounds in the first month. My idea was to never increase the dose because I didn’t want to take this forever. Thus I stalled out at -8 pounds on .25ml dose. The biggest problem for me was side effects - I was guaranteed to get one rock hard poop a few days after the shot. It was horrible so I quit.

Imagine if Jan didn’t take a full two months off the bike, and party like it’s 1999 the whole time, and show up in January totally out of shape. :slight_smile:

In any case, it’s legal if Pros want to take it. It’s not going to turn a donkey into a race horse.

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He wouldn’t. That’s my whole point.

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So already quite strong though for your height

And Ullrich was an idiot who secured his place in history as 2nd banana with his methods.

I mean, look, I don’t like the guy either. Not sure what that has to do with the conversation though.

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Not many pros are starting with a BMI of 38 like OP was…

That’s not the point, but I don’t want to take over OP’s thread talking about pros. :metal:

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If you look back about 2 months or so the Nero Show had a show talking about this. The lead coach went on it and he had the same experience of weight loss but also being unable to get any power out. He I think was talking similarly to cnidos above as to why that might be. His thinking was that it’d be something to do during the off season but not during a training block or race season.

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Congrats on the weight loss! Congrats on keeping the FTP! And most importantly congrats on the little one!

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Bad idea there is an interview on roadman podcast

Sure about that? The liver creating glucose is not a fast pathway especially during high intensity exercise. It’s a refill mechanism.